The research partnership establishedbetween MSSRF and CSIR-NIIST, Thiruvananthapuramsince 2014 has resulted in publication of four papers inhigh impact journals. The evidences are in validation of some of the claims on the efficacy and medicinal benefits of the plant species known to the tribal community of Wayanad district. The papers are on (i) isolation, characterization and anti-inflammatory activity of the compounds isolated from the stem bark of H. parviflora; (ii) isolation and characterization of resveratrol oligomers from the stem bark of Hopea ponga; (iii) Dihydro-β-agarofuransesquiterpenoids from the seeds of Celastrus paniculatus, and (iv) Comparison of antidiabetic potential of (+) and (−)-hopeaphenol, a pair of enantiomers isolated from Ampelocissus indica (L.) and Vateria indica Linn., with respect to inhibition of digestive enzymes and induction of glucose uptake in L6 myotubes. Read these papers in following Links:
Study by Ratheesh and Anil Kumar (unpublished) in the district among the different ethnic groups have revealed there are 434 flowering plants used by the tribal people of Wayanad of which 184 are of food use, 244 are of medicinal use, 7 species are used for extracting fibres and 68 plants are recorded for other uses like fish poisoning, magico-religious, canes, resins and as other Minor Forest Produces. The MoU between MSSRF and CSIR-NIIST is being renewed and research will be continued on the priority species listed in the report of Ratheesh and Anil Kumar (2012).
List of MSSRF and CSIR-NIIST Joint publications
- Anti-inflammatory effect and mechanism of action of ellagic acid-3, 3′, 4-trimethoxy-4′-O-α-L-rhamnopyranoside isolated from Hopeaparviflora in lipopolysaccharide-stimulated RAW 264.7 macrophages, B. Prabha, S. Sini, P. Sasikumar, Greeshma Gopalan, Jayesh P Joseph, M. M. Jithin, V.V. Sivan, P. Jayamurthy and K. V. Radhakrishnan, Natural Product Research, 2019, DOI:10.1080/14786419.2019.1690486. https://www.tandfonline.com/doi/abs/10.1080/14786419.2019.1690486?tab=permissions&scroll=top
- Isolation and characterization of resveratrol oligomers from the stem bark of Hopea ponga (Dennst.) Mabb. And their antidiabetic effect by modulation of digestive enzymes, protein glycation and glucose uptake in L6 myocytes. Sasikumar P, Lekshmy K, Sini S, Prabha B1, Kumar NA, Sivan VV, Jithin MM, Jayamurthy P, Shibi IG, Radhakrishnan KV. J Ethnopharmacol.2019, 236, 196–204.
https://www.sciencedirect.com/science/article/abs/pii/S0378874118312224?via%3Dihub
- Dihydro-β-agarofuransesquiterpenoids from the seeds of Celastrus paniculatus Willd. and their α-glucosidase inhibitory activity. P. Sasi kumar , P. Sharathna , B. Prabha, Sunil Varughese, N. Anil Kumar, V. V. Sivan, D. R. Sherin, E. Suresh, T. K. Manojkumar V. Radhakrishnan. Phytochemistry Letters, 2018, 26, 1-8.
https://www.sciencedirect.com/science/article/abs/pii/S1874390018300120
- Comparison of antidiabetic potential of (+) and (−)-hopeaphenol, a pair of enantiomers isolated from Ampelocissusindica (L.) and Vateriaindica Linn., with respect to inhibition of digestive enzymes and induction of glucose uptake in L6 myotubes. P. Sasikumar, B. Prabha, T. R Reshmitha , Sheeba Veluthoor, Pradeep kumar, K. R Rohit, P Dhanya, V. V Sivan, M.M. Jithin, N. Anil Kumar, P. Nisha and K. V. Radhakrishnan. RSC Advances, 2016, 6, 77075-77082. https://pubs.rsc.org/en/content/articlelanding/2016/RA/C6RA14334B#!divAbstract
